The endocannabinoid system plays an important role. Endocannabinoids regulate our metabolism, with external cannabinoids, CB1 and CB2 binding to our cannabinoid receptors.
Researchersfrom theUniversity of Tel Aviv alsodiscoveredthat cannabinoid receptors within our bodies stimulated bone formation and inhibited bone loss. This paves the way for the future use of cannabinoid drugs to combat osteoporosis and other bone-related diseases.
According to Dr. Gabet, of the Bone Research Laboratory at the Department of Anatomy and Anthropology at TAU's Sackler Faculty of Medicine and the late Prof. Itai Bab of Hebrew University's Bone Laboratory, “Our bodies are equipped with a cannabinoid system, which regulates both vital and non-vital systems. "We only respond to cannabis because we are built with intrinsic compounds and receptors that can also be activated by compounds in the cannabis plant," he said. The researchers found that the skeleton itself is regulated by cannabinoids. Even the addition of a non-psychogenic compound acting outside of the brain can affect the skeleton,” via Science Daily.
"The clinical potential of cannabinoid-related compounds is simply undeniable at this point," said Dr. Gabet. "While there is still a lot of work to be done to develop appropriate therapies, it is clear that it is possible to detach a clinical therapy objective from the psychoactivity of cannabis. CBD, the principal agent in our study, is primarily anti-inflammatory and has no psychoactivity,” says Dr. Gabet.
The researchers concluded the following "We found CBD alone to be sufficiently effective in enhancing fracture healing," said Dr. Gabet. "Other studies have also shown CBD to be a safe agent, which leads us to believe we should continue this line of study in clinical trials to assess its usefulness in improving human fracture healing."
The latest research has also demonstrated that CBD may have beneficial therapeutic effects, and can help combat anxiety, epilepsy, tumor growth and more. It may also help to promote your dog’s skin and coat health, and may also reduce brain neuron inflammation in both pets and people.
A 2018 study from Cornell University adds that “TheCornell study found that dogs who took ElleVet's proprietary hemp oil blend showed significant improvement over dogs that received the placebo. The study determined that ElleVet's hemp oil blend is "efficacious for pain in dogs with osteoarthritis, chronic joint pain, and geriatric pain and soreness; with dramatic beneficial effects in our more geriatric patients." Over 80% of dogs who have used ElleVet Mobility soft chews have seen a significant or dramatic improvement. Veterinarians have called ElleVet soft chews, "A game-changer that will change the face of veterinary medicine," via Cornell University.
In a2019study publishedin the American Society of Microbiology, it was found that CBD may soothe many bacterial skin diseases because of its anti-inflammatory properties. Mice with melanoma had increased inhibition of tumor growth. It also reduced swelling and inflammation in mice.
Another interesting smallerstudy done in Canada demonstrated how CBD oil helps reduce the pain of skin wounds, abrasion, injuries, and burns. In cases where patients would normally have relied on opioids for intense pain, patients using CBD oil found relief. Here’s what the study mentions.
“The ideal methods of pain relief for wound patients are modalities that are topical, lack systemic side effects, noninvasive, self-administered, and display rapid onset of analgesia. Extracts derived from the cannabis plant have been applied to wounds for thousands of years. The discovery of the human endocannabinoid system and its dominant presence throughout the integumentary system provides a valid and logical scientific platform to consider the use of topical cannabinoids for wounds. We are reporting a prospective case series of three patients with pyoderma gangrenosum that were treated with topical medical cannabis compounded in nongenetically modified organic sunflower oil. Clinically significant analgesia that was associated with reduced opioid utilization was noted in all three cases. Topical medical cannabis has the potential to improve pain management in patients suffering from wounds of all classes,” via PubMed.