CBD breaks down peroxynitrite on contact. Because it’s an antioxidant, it prevents the formation of peroxynitrite inside the cell. CBD may prevent blindness by preventing apoptosis of neurons. That said, CBD with CBN, and CBG may help with glaucoma in dogs.
A 2003 study demonstrated that “in glaucoma, the increased release of glutamate is the major cause of retinal ganglion cell death. Cannabinoids have been demonstrated to protect neuron cultures from glutamate-induced death, “via PubMed. This study concluded that “The effect of THC was in part mediated by the cannabinoid receptor CB1. These results suggest the potential use of CBD as a novel topical therapy for the treatment of glaucoma.”
A 2006 pilot study wanting to assess the effect on intraocular pressure (IOP) and the safety and tolerability of oromucosal administration of a low dose of delta-9-tetrahydrocannabinol (Delta-9-THC) and cannabidiol (CBD) on people stated the following, “A single 5 mg sublingual dose of Delta-9-THC reduced the IOP temporarily and was well tolerated by most patients. Sublingual administration of 20 mg CBD did not reduce IOP, whereas 40 mg CBD produced a transient increase IOP rise,” via PubMed.
That said the use of CBD oil for glaucoma has been backed up by several studies. In a 1984 study, “intraocular pressure, ocular toxicity, and neurotoxicity after administration of cannabinol or cannabigerol lowers ocular tension considerably. While cannabinol had a modest effect on intraocular pressure after a single dose, it caused a more significant reduction in ocular tension during chronic administration. Cannabigerol had similar effects, but the magnitude of response to its chronic administration was greater,” via PubMed.
This study suggests that the use of hemp-based products and cannabis supplements, when administered in the right dosage, proved effective in treating glaucoma in dogs. As usual, consult with your veterinarian for the best CBD oil products for dogs with glaucoma is recommended. That said, hemp-based CBD pet products offer all the chemicals from the hemp plant which includes CBD, CBN, and CBG, as well as numerous other compounds like terpenes and cannabinoids.